Risk of COVID-19 hospital admission among children aged 5 to 17 with asthma in Scotland: A national incident cohort study
Evidence before this study
Understanding which children with asthma are at increased risk for serious complications from COVID-19 is of critical importance in vaccine prioritization deliberations. We searched PubMed, medRxiv and SSRN for observational studies, without language restrictions, using the terms “SARS-CoV-2”, “COVID-19”, “children”, “adolescents”, “young adults” and “ asthma ”, for studies published between March 1, 2020 and October 7, 2021. We did not identify any studies examining the risk of severe outbreaks of COVID-19 in children with varying severity or with asthma control . Previous work has shown that adults with poorly controlled asthma are at increased risk of serious consequences from COVID-19.
Added value of this study
To our knowledge, this is the first national study to assess the risk of hospitalization for COVID-19 in children aged 5 to 17 with markers of uncontrolled asthma. We found that children with poorly controlled asthma (defined by either a previous hospitalization for asthma or a prescription for oral corticosteroids) had an increased risk of COVID-19 hospitalization compared to those with well-controlled asthma. or without asthma. The risk ratio was significant after adjusting for age, sex, socioeconomic status, comorbidity, and previous hospitalization.
Implications of all available evidence
We provide national evidence that children and youth aged 5 to 17 with poorly controlled asthma are at increased risk of hospitalization for COVID-19. These findings were used to inform deliberations on children aged 12 to 15 to be preferred for COVID-19 vaccination. Consideration should be given to extending the vaccination offer to the youngest.